Amgen to Showcase Cutting-Edge Research from Extensive Oncology Portfolio at ASCO 2024

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Amgen today announced the presentation of new data from its broad oncology portfolio at the American Society of Clinical Oncology (ASCO) 2024 Annual Meeting, taking place from May 31-June 4 in Chicago. The 17 abstracts from Amgen-sponsored and partner-led studies, including one late-breaking oral presentation, demonstrate Amgen’s commitment to innovation and meaningfully improving outcomes for people living with difficult-to-treat cancers.

“At this year’s ASCO, we’re thrilled to present strong clinical research data with our medicines that target some of the most devastating cancers,” said Jay Bradner, M.D., executive vice president, Research & Development, and chief scientific officer at Amgen. “Our focus is on molecular targets that we believe play a fundamental role in cancer progression, and by attacking these with our innovative combination therapies, we aim to bring real improvements in patient outcomes. Notably, we are advancing T-cell Engager therapies in both hematologic and solid tumors, and we are exploring LUMAKRAS plus Vectibix as a potentially practice-changing approach to metastatic colorectal cancer.” 

Subgroup analysis of the Phase 2 DeLLphi-301 study demonstrated durable anticancer activity in relapsed/refractory small cell lung cancer (SCLC) regardless of the presence of treated, stable brain metastases at baseline. Analysis of intracranial activity will be presented.

Research from a Phase 1b study (DeLLpro-300) showcasing IMDELLTRA safety results with encouraging anti-tumor activity in DLL3-expressing de novo or treatment-emergent neuroendocrine prostate cancer (NEPC).

Data from the global, registration-enabling Phase 3 CodeBreaK 300 study, evaluating LUMAKRAS combined with Vectibix in chemorefractory KRAS G12C-mutated metastatic colorectal cancer (mCRC) was accepted as a late-breaking abstract and will report overall survival (OS) results.

Updated analysis from the global Phase 1b CodeBreaK 101 study showing that LUMAKRAS plus chemotherapy had a positive benefit-risk profile, durable responses, and long-term control in patients who had or had not received prior treatment for KRAS G12C-mutated advanced non-small cell lung cancer (NSCLC).